Fatigue? Trouble focusing? Low mood? Vitamin B6 could be the key you’ve been missing. Often overshadowed by other B-vitamins, B6 is essential for brain health, hormone balance, energy production, and even inflammation control.
And while most recommendations aim at minimum requirements, new research shows that higher doses may offer additional benefits.
Let’s dive into the science and see why this overlooked nutrient might be one of the best additions to your stack.
What Is Vitamin B6 and Why Do You Need It?
Vitamin B6 refers to a group of water-soluble compounds: pyridoxine, pyridoxal, and pyridoxamine. The active form, pyridoxal 5’-phosphate (PLP), is a coenzyme involved in over 150 biochemical reactions in the body - especially those linked to the nervous system, mood, metabolism, and immune function.
Core Roles:
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Neurotransmitter synthesis: It helps produce dopamine, serotonin, and GABA—key players in mood, focus, and stress management.
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Energy production: B6 supports glycogen breakdown to release glucose for energy.
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Hormonal balance: Involved in estrogen metabolism and often used to reduce PMS symptoms.
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Hemoglobin production: Assists in red blood cell creation, essential for oxygen delivery.
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Immune defence: Supports the production of immune cells and inflammatory regulation.
Where Can You Get Vitamin B6?
You’ll find B6 in foods like:
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Meat and fish (chicken, tuna, salmon)
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Potatoes, bananas, and avocados
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Nuts and seeds
However, B6 is heat- and light-sensitive, and cooking destroys much of it—especially in plant-based diets. This makes supplementation an easy and reliable option.
What is the optimal dose of Vitamin B6?
The standard recommendation is around 1.4–1.6 mg per day—but recent studies show that higher doses (10–30 mg) can unlock additional benefits, especially in people with stress, high training demands, mood issues, or inflammation.
Here’s what the science says:
1. Improved Cognitive Function and Mood
A randomised clinical trial published in Frontiers in Pharmacology (2021) found that high-dose B6 (300 mg/day)significantly improved cognitive function and reduced symptoms of schizophrenia (1). While that’s a much higher dose than what's recommended, it shows how B6 directly influences brain chemistry - even at high levels.
2. Reduced Inflammation
A 2023 study in Biomedicines showed that B6 down-regulates pro-inflammatory genes (IL-1β, IL-6, TNF-α) in monocytes, making it a promising anti-inflammatory nutrient—especially in the context of chronic stress, intense training, or modern inflammatory diets (2).
3. Enhanced Hormonal Support (PMS, Estrogen Balance)
Vitamin B6 is often used to alleviate PMS symptoms, including mood swings, irritability, and bloating. A meta-analysis found that doses ranging from 10–100 mg/day can reduce PMS symptoms, likely through dopamine and serotonin regulation and improved estrogen metabolism (3).
4. Improved Energy Levels and Focus
Because B6 is critical in carbohydrate metabolism, it helps regulate energy levels and maintain stable blood sugar. It also plays a role in reducing brain “fog” by facilitating neurotransmitter function.
Higher intakes, like 10–20 mg, have been linked to improved mental performance in demanding cognitive situations.
Benefits of Choosing Vitamin+
Each daily dose of Vitamin+ contains 15 mg of Vitamin B6—that’s over 800% of the RDA, but still well below the 25–100 mg range used safely in clinical studies (4).
This dose provides all the benefits of higher B6 intake:
✅ Boosted mood
✅ More stable energy
✅ Reduced inflammation
✅ Hormonal support
✅ Better focus
And because Vitamin+ is paired with other high-quality nutrients, it works synergistically for everyday performance and well-being.
References :
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High-dose Vitamin B6 improves cognition in schizophrenia – Frontiers in Pharmacology, 2021
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B6 improves mental performance and mood – J Int Med Res, 2007
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